The Plymouth Business School is to work with UMASS' College of Management as part of the partnership. Plymouth said the agreement with complement its existing international links already in place with Brazil, China, India, Hong Kong and Sri Lanka.
The partnership will include exchange programmes for students from both universities as well as collaborative research initiatives. The two institutions will also work together to explore potential entrepreneurial projects.
Professor David Wheeler, dean of the Plymouth Business School, said: "Plymouth University has found a true friend in UMASS Boston. We share common values, a commitment to sustainability, and an active interest in the history and future of transatlantic relations.
"There are collaborative research projects already in existence, and we will be making proposals for joint programmes, significantly enhancing the opportunities for exchanges so our students can further deepen the relationship."
UMASS chancellor J. Keith Motley added: "UMASS Boston is training the next generation of global citizens, and we welcome this wonderful opportunity to partner with Plymouth University in this effort.
"Our agreement enables students from both these great institutions to draw on the expertise of leading thinkers and innovators from around the world."