The retailer is opening two shops at Manchester Airport, one in terminal one and one in terminal two.
The first store opened on Sunday and the second is to open tomorrow (7 February 2013).
The retailer said the brand was a "welcome addition" to retail options at the airport following feedback for more child friendly areas.
Last month, WH Smith revealed sales in its travel division were flat in the 20 weeks to 20 January but that it had "further opportunities for growth".
Simon Smith, WH Smith travel chief operating officer, said: "We are delighted to be opening our first Zoodle by WH Smith stores in the UK at Manchester Airport, just before half term and well ahead of the summer peak.
"We are very much looking forward to providing children and their families with everything they need before they fly."
WH Smith is set to announce its full year financial results in April.