Australian property giant Goodman and Yorkshire-based Shepherd Group have entered into a partnership to develop the plans and will work with the Etwall site's owner Etwall Land.
The scheme, which could create up to 6,000 new jobs, is expected to be the biggest ever planning application in the history of south Derbyshire.
Charles Crossland, managing director of Goodman UK Logistics, said: "Goodman has proven experience globally in developing this type of project which offers enormous potential for businesses looking to benefit from a modern industrial precinct with excellent location and transport links.
"From an economic viewpoint, the new strategic rail freight hub will act as a stimulus to attract further investment into the area and enhance the region's reputation as a key business location."
Mark Perkins, chief executive of Shepherd Group Built Environment, added: "We will seek to play a positive and beneficial role in delivering this exciting regeneration project and look forward to working with all stakeholders to ensure the very best outcome for all concerned."
A public consultation process is now underway.